In the T2DM group, betatrophin amounts were correlated only with age and HDL-cholesterol levels; meanwhile, serum betatrophin concentrations were associated with multiple metabolic parameters, including fasting glucose, WHR, insulin, C peptide, HOMA-IR, QUICK index, and lipid profiles (TG and HDL-C) in the NDM group (Table 2). The gene discussed is ANGPTL8; the disease is type 2 diabetes mellitus.