Trex1 (-/-) mice lacking cGAS are completely protected from lethality, exhibit dramatically reduced tissue inflammation, and fail to develop autoantibodies, implicating cGAS as a key driver of autoimmune disease and suggesting that cGAS inhibitors may be useful therapeutics for Aicardi-Goutières syndrome and related autoimmune diseases [9]. Here, TREX1 is linked to autoimmune disease.