POLDIP3 and cancer: While the study of PDIP46/SKAR functions are still at an early stage, it is nevertheless apparent that even within its currently known properties that it has the potential to play a role in the cancer process, either in terms of genomic stability directly by affecting DNA replication at the core level of synthesis and fidelity, or in terms of growth regulation and its role in transducing expression of replication and signaling proteins or anti-neoplastic factors as described above.