Around rs67839313, there are two plausible genes for susceptibility to T2D: PLCB2 and DISP2. PLCB2 encodes phospholipase C isoform β-2 and phospholipase C is a known regulator of insulin secretion through hydrolysis of islet phosphoinositide pools35. This evidence concerns the gene PLCB2 and type 2 diabetes mellitus.