GSK3B interacts with NOTCH1, NOTCH2 and CCND2, whereas JUN interacts with FBXW7, HHEX and CCND2. Eight genes interact with 2 biological T2D risk gene products and 68 genes interact with a single biological T2D risk gene product (Supplementary Table 21). The gene discussed is NOTCH1; the disease is type 2 diabetes mellitus.