Nonetheless, how lysosomal cholesterol accumulation in macrophages renders CD38−/− mouse an atherosclerotic inclination in coronary artery rather than the aorta and aorta root, the bounded atherosclerotic lesions as seen in the empirical LDLr−/− and ApoE−/− atherosclerosis mouse models, is subject to further explore. The gene discussed is APOE; the disease is atherosclerosis.