Interestingly, although Snail play a pivotal role in the regulating of EMT, multivariate survival analysis shown that Snail expression was not an independent prognostic factor (P = 0.97), whereas HMGA2 was (P = 0.042), implying that HMGA2 may be an independent prognosis biomarker in the tongue squamous cell carcinoma. This evidence concerns the gene HMGA2 and tongue squamous cell carcinoma.