Thus, to examine whether the involvement of the RELMβ in the colon or that in Kupffer cells, or both, is critical for NASH development, mice lacking RELMβ in either non-hematopoietic or hematopoietic cells were produced by BMT between RELMβ-KO and wild-type mice. The gene discussed is RETNLB; the disease is metabolic dysfunction-associated steatohepatitis.