TRIB3 and Insulin resistance: 2010; Matos et al. 2010). Thus, we tested whether TRIB3 mRNA might be increased, suggesting it could contribute to the skeletal muscle insulin resistance observed following polytrauma. TRIB3 mRNA levels were measured at 6 h and 24 h following injury. At 6 h, burn/CLP resulted in a modest, but significant increase in TRIB3 mRNA levels versus sham/sham (Fig. 5D).