Whereas proteins that regulate interferon-beta production (LY96 and TLR4), apoptotic signaling (HSP90AA1, LRRK2, TGFBR2, FASLG, CASP8,), bacterial invasion (SEPT1 and SEPT6), and Wnt signaling pathway (HIC1 and CTBP2) seemed to represent the underlying variations between TB and healthy controls, the differences between TB and LTBI might be contributed by proteins that modulate transcription (FOS and DDIT3), phagosome formation (TUBA1A and TUBB4B), autophagy (CASP8 and TNFRSF10B), and interferon-gamma signaling (ARRB2, PTAFR, NFKBIA). This evidence concerns the gene CASP8 and tuberculosis.