In addition, Fig. 2b presents an MI changing five amino acids of gene JMJD4 and overlapping with 5’UTR of gene SNAP47. While JMJD4 is a member of JmjC-domain-only family, which only contains the JmjC domain, and plays an important role in demethylation and involves in cancer diagnosis [31]. This evidence concerns the gene JMJD4 and cancer.