BRAF and neoplasm: The observation of neuroglial tumours with BRAF V600E mutation acquiring a AT/RT-like phenotype on SMARCB1 loss39 illustrates that some cells with abnormal genetic background may tolerate SMARCB1 loss and undergo malignant transformation with a rhabdoid phenotype, without being actual AT/RT, restrictedly defined as an infant disease characterized by a remarkably simple genome.