This age and sex distribution is similar to previous reports in Asian populations.25 Recent advances in our knowledge of the pathogenesis of AD have posited the relationship between immune dysregulation, and skin barrier abnormalities.13,14 Exposure to irritants and allergens from barrier-defective skin in patients with AD may lead to a specific Th2 cell activation and IgE production in a subset of these patients. This evidence concerns the gene IGHE and Alzheimer disease.