In addition, in a model comprising several variables relevant to the risk of death, including age, sex, smoking habits, BMI, HbA1c, total cholesterol, HDL-cholesterol, triglycerides, insulin therapy and hypertension, both the same allele at rs822354 (IRR = 1.94, 95 % CI 1.23–3.07; p = 0.005), as well as the genetic equivalent of total adiponectin change (IRR = 1.07, 95 % CI 1.02–1.12; p = 0.003), were significantly associated with CV mortality. Here, INS is linked to hypertensive disorder.