The overexpression of MMP‐13 has been documented in previous reports of breast cancer 26, squamous cell carcinoma of head and neck 27, lung cancer 28, malignant melanoma 29, colorectal cancer 30, oral squamous cell carcinoma 31, colorectal adenoma and carcinoma 32, and glioma 33. This evidence concerns the gene MMP13 and oral cavity squamous cell carcinoma.