IL6 and neoplasm: Experimental studies have proven that a hypercoagulable status can be induced directly by the tumor cells themselves or indirectly by the tumor-associated cytokines that are produced by host macrophages or endothelial cells [2, 12, 13], and interleukin-6 (IL-6) has been found to be a key regulator of paraneoplastic thrombocytosis and hyperfibrinogenemia [2, 12–15].