ENPP2 and neoplasm: Extracellular lysoPCs are converted into lysophosphatidic acid (LPA), which induces tumor growth, by autotaxin (ATX), a secreted lysophospholipase D. Overexpression of ATX and LPA receptors has been proposed to be a common feature of several cancers, and both ATX and LPA receptor knockout mice show lower cancer risk [22–24].