Recently, F Neri et al. reported the downregulation of TET1 messenger RNA (mRNA) expression level, but not other two TET family members, in colon cancer and showed that decreased TET1 mRNA was crucial for colon cancer initiation and TET1 functioned as a tumor suppressor by inhibiting the WNT pathway [1]. This evidence concerns the gene TET1 and malignant colon neoplasm.