In addition, these mice also showed to be resistant to the deleterious effects of thyrotoxicosis on bone microstructure and biomechanical properties, bringing new evidence that the regulation of bone remodeling by the SNS is extremely complex and that TH, when in supraphysiological levels, interacts with this system to control bone remodeling and structure in an α2C-AR subtype-dependent manner. The gene discussed is TH; the disease is thyrotoxicosis.