PTGIS and pulmonary arterial hypertension: In this study, we examined the expression of a panel of miRNAs in the monocrotaline (MCT) PAH rat model, evaluated the functional role of a specific miR-223 inhibitor on attenuation of PAH, and determined the results of human prostacyclin synthase (hPGIS)-mediated attenuation of MCT PAH on this miRNA panel.