We would not expect the increase in P53 acetylation to be caused by the HD-related dysregulation of acetyltransferases as it has been shown that the P53 acetyltransferases: CREB binding protein, P300 and P300/CBP associated factor, are inhibited with disease progression in HD [49] and would therefore be expected to result in a reduction in P53 acetylation, the opposite to that observed in this study. This evidence concerns the gene EP300 and Huntington disease.