In addition, degradation of connexins 43 has been reported, hindering theconduction of the electrical stimulus between myocytes.5 Thus, the cardiac tissue transforms into connective tissue, leading tothe appearance of zones of fibrosis of slow conduction that manifest as VLP on the SAECG.The increase in the zones of fibrosis hinders myocardial contractility, and graft lossbecomes inevitable. This evidence concerns the gene GJA1 and fibrosis.