RASAL1 and hyperphosphatemia: In summary, we observed that presence of 3mM inorganic phosphate (reminiscent of serum phosphate levels observed in patients with hyperphosphatemia) induces EndMT in cultured HCAEC and that this phenotypic conversion was associated with aberrant methylation of the Ras-GTP inhibitor RASAL1, an event known to facilitate EndMT in HCAEC.