YSJB pill is a potentialanti-rheumatic agent targeting the inflammatory and immunomodulatory response ofmacrophages, it has been reported to be able to significantly decrease the production ofperitoneal macrophages derived TNF-α, IL-1 and NO of serum, and decrease the TNF-alpha mRNA,IL-1beta mRNA, and caspase-3 expression in synoviocytes in Freund's complete inducedadjuvant arthritis (AA) in rat model49, 50. This evidence concerns the gene TNF and arthritic joint disease.