LEPR and diabetes mellitus: Induction of diabetes in eNOS−/− mice by administration of streptozotocin [52] or by crossing to leptin-receptor deficient db/db mice [53] reproduces many features typical of human DN including the following: early onset albuminuria, decreased GFR, arteriolar hyalinosis, mesangial expansion, mesangiolysis, and nodular glomerulosclerosis.