KLK3 and posterior cortical atrophy: PMP levels were significantly higher in CRPC and treatment naive metastatic PCa patient plasmas (Figure 3A-3D, *denotes p < 0.05, one-way ANOVA) when compared to those from localized PCa patients but did not exhibit significant correlation with serum PSA values (R2 = 0.42, p > 0.17).