In a survey of constitutive and activated STAT3 expression and MM therapy, STAT3 was found highly expressed in more than 63% of CD138+ bone marrow cells of primary MM patients [14] and the highly activated STAT3 is associated with chemoresistance to most of the standard therapies [13], including dexamethasone [14]. The gene discussed is SDC1; the disease is Miyoshi myopathy.