Overall, 34 out of 47 analytical comparisons (72%) reported statistically significant elevated mean or median PAI-1 (antigen or activity) among T2D cases as compared to controls, 2 (4%) reported statistically significant elevated mean PAI-1 antigen among controls versus cases, and 11 (24%) reported no association of PAI-1 with outcome status. Here, SERPINE1 is linked to type 2 diabetes mellitus.