Similarly, an initial increased risk of T2D with elevated PAI-1 activity in Eliasson et al. was no longer significant after adjustment for fasting insulin, diastolic blood pressure, and triglycerides, though this may have led to over-parameterization in their model owing to the limited number of incident diabetes cases in the study (n=15)10. Here, SERPINE1 is linked to type 2 diabetes mellitus.