That other circulating markers of endothelial dysfunction such as coagulation factor VIII, E-selectin, intercellular adhesion molecule-1, and tPA have also been found to predict T2D10, 33, 34, 35, 36, 37, also supports a role of PAI-1 in the pathogenesis of T2D. The gene discussed is SERPINE1; the disease is endothelial dysfunction.