Although a close association was observed between SF mutations and mutations in certain genes, especially those related to epigenetic modifications, in MDS (such as SF3B1 mutation with DNMT3A mutation, SRSF2 mutation with mutations of RUNX1, IDH and ASXL1 genes and U2AF1 mutation with mutations of ASXL1 and DNMT3A),[4, 6, 18, 19], little is known about the interaction between SF mutations and other molecular genetic alterations in AML patients. This evidence concerns the gene DNMT3A and acute myeloid leukemia.