In the 66 septic patients with HF, the median plasma NT-proBNP levels of mild, moderate, and severe HF were 1348.22 ng/L (n = 32), 3472.15 ng/L (n = 19), and 4236.23 ng/L (n = 11), respectively; the differences among them were significant (x2 = 41.13, P < 0.001). Here, NPPB is linked to hydrops fetalis.