CD4 and lymphoma: The proportion of CD4+IFN-γ-producing T cells (Th1 subset) was significantly higher in patients with lymphomas (median, 25.3% of CD4+ T cells; range, 5.7–72.1%; n = 48) than that in normal individuals (median, 17.6%; range, 7.9–48.9%; n = 39; P = 0.0030) (Fig 2C).