SMARCA1 and esophageal squamous cell carcinoma: In this study, we aimed to clarify, in ESCC, 1) what components of the SWI/SNF complex have somatic mutations by deep sequencing using a bench-top next generation sequencer to overcome the intrinsic limitation in the reading depth of exome-sequencing, 2) what components have aberrant methylation, and 3) when somatic mutations of the SWI/SNF complex occur.