Components of the SWI/SNF complex, ACTL6B, SMARCA2, and SMARCD3, and those of the other types of chromatin remodeling complex, ATRX and SMARCA1, are aberrantly methylated in gastric cancers [13]; ARID1A in invasive breast cancers [19]; ARID1B in pancreatic cancers [20], and ACTL6B in hepatocellular carcinomas (HCCs) [21]. The gene discussed is ACTL6B; the disease is familial pancreatic carcinoma.