WIPI1 and neurodegeneration with brain iron accumulation 5: WDR45 is a redundant, non-core autophagy gene, one of four mammalian homologs to Atg18, and mutations in WDR45 cause SENDA, static encephalopathy of childhood with neurodegeneration in adulthood (Haack et al., 2012; Saitsu et al., 2013).