Recent studies have revealed that the unique abnormalities of coagulation and fibrinolytic function are associated with increased amounts of tissue factor(TF), cancer procoagulant (CP) as well as elements of the fibrinolytic system, including tissue plasminogen activator, annexin A2, and plasminogen activator inhibitor type 1 expressed by leukemic promyelocytes in APL [20]. This evidence concerns the gene ANXA2 and acute promyelocytic leukemia.