Previously, we and others showed that α-GalCer administration before OVA immunization increases serum levels of IgE, Th2 cytokines, airway hyperreactivity (AHR), and airway eosinophilia after OVA rechallenging in the OVA-alum immunized murine model of allergic asthma [21, 29–31]. The gene discussed is IGHE; the disease is allergic asthma.