BAK1 and cancer: Consistently, AMPK inhibitor compound C (CC) suppressed the hernandezine-induced autophagy and cell death in Bax-Bak DKO MEFs (Figures 6D and 7A), whereas CC also abrogated hernandezine-induced cell death in DLD-1 Bax-Bak DKO cancer cells (Figure 7B), confirming the key role of AMPK signalling in hernandezine-induced cell death of apoptosis-resistant cancer.