CoQ and polyphenol activate AMPK signaling via the upstream kinases, Ca2+–stimulated kinase (CaMKK) and liver kinase B1 (LKB1), which are correlated to their therapeutic potency upon different disease conditions such as obesity, hyperglycemia and insulin resistance [33–35]. The gene discussed is CAMKK2; the disease is obesity due to melanocortin 4 receptor deficiency.