On the other hand, the depletion of PLCγ1 by shRNA3 led to the decrease in CD34 (one of biomarkers of vascular density) and VEGF protein levels, and VEGF mRNA level in tumor tissue, indicating the involvement of PLCγ1 in the angiogenesis of tumor (Figure 3D, *P < 0.05, ****P < 0.0001, vs control). Here, PLCG1 is linked to neoplasm.