The depletion of PLCγ1 by shRNA3 led to the decrease in p-Akt, p-ERK1/2, p-Bad (Ser112), p-Bad (Ser136), and p-S6 (Ser235/236) levels in tumor tissue of human gastric adenocarcinoma xenografts in vivo (Figure 4B, *P < 0.05, **P < 0.01, ***P < 0.001, vs control). This evidence concerns the gene MAPK3 and gastric adenocarcinoma.