For example, STAT3 contributes to colorectal tumorigenesis through interaction with PLCγ1 [10]; the combined activation of PLCγ and MAPK is required for FGFR3-induced epithelial to mesenchymal transition (EMT) [11]; and FGF induces G2/M transition via the Akt/PLCγ1 axis in MDA-MB-231 breast cancer cells [12]. This evidence concerns the gene AKT1 and breast cancer.