Subsequently, based on forward stepwise logistic regression with predictive variables from Table 3 (i.e. tumour volume, Knosp classification for macroadenomas and tumour pseudocapsule for microadenomas, ultrastructure and MIB1 LI), we showed that the lack of immediate and early remission significantly depends on tumour volume (Ptrend=0.005 and Ptrend=0.006 respectively) and the variable describing the invasiveness of corticotroph tumours (P=0.004 and P=0.007 respectively). Here, MIB1 is linked to neoplasm.