(ii) We performed a cell staining strategy that allowed us to identify two different subpopulations of circulating DCs (lin-1-/HLA-DR++/CD11c+/CD123-, myeloid DCs and lin-1-/HLA-DR++/CD11c-/CD123+, plasmacytoid DCs) but a more detailed DC characterization by BDCA’s analysis [54] may prove useful to identify further distinctive DC subsets involved in AD. Here, CD2BP2 is linked to Alzheimer disease.