Importantly, the recent and accurate description of a CNS lymphatic system connected to deep cervical lymph nodes, which are able to drain cerebrospinal fluid and carry immune cells such as CD11c+ [45], leads to more thorough investigation of the leukocyte presence in CNS immune responses in neurodegeneration and supports our hypothesis about blood-derived DC involvement in AD brain pathology. Here, ITGAX is linked to Alzheimer disease.