One week after last treatment, although E7 DNA vaccine plus α-GalCer and MPL combination mice in the presence of isotype control had significantly greater protection compared to DNA vaccination in the presence of isotype control mAbs, there was no additional tumor volume growth observed in E7 DNA vaccine plus α-GalCer and MPL combination mice in the presence of anti-IL-18 mAbs (data not shown). Here, IL18 is linked to neoplasm.