2012), we determined whether increased uterine artery myogenic tone could be due partly to loss of RGS2 in uterine artery endothelium. Stimulation of uterine arteries with increasing concentrations of acetylcholine caused similar vasodilatory responses in uterine arteries from WT, Rgs2+/−, and Rgs2−/− mice (data not shown), indicating the absence of endothelial dysfunction in the augmented uterine artery myogenic tone in Rgs2−/− mice. Here, RGS2 is linked to endothelial dysfunction.