2014; Patel and Brackenbury 2015). Most Na+ channel α‐subunits, including Nav1.5, were indeed shown to enhance migration and invasion of various types of cancer cells, thereby promoting metastasis. Na+ channels have also been linked to migration, endocytosis, and secretion of human aortic smooth muscle cells (Meguro et al. 2009), as well as angiogenesis (Andrikopoulos et al. 2011). Here, SCN5A is linked to cancer.