ALB and cirrhosis of liver: Despite multiple studies, including systematic reviews,12, 13 evaluating albumin in septic intensive care patients there is a lack of interventional RCTs in patients with liver cirrhosis in which the mechanism of albumin's action is different.14–16 To date there has not been an albumin dosing trial aimed at increasing serum albumin levels in this context therefore it was essential that this was completed before proceeding to a large, interventional RCT.