It is well known that tumor recruited macrophages can support tumor progression [17]; conversely, macrophages activated by microbial products (i.e., TLR ligands and NOD specific agonists) and pro-inflammatory cytokines (i.e., Interferon gamma and Tumor necrosis factor (TNF) alpha) have shown antitumor activity [18]. The gene discussed is TNF; the disease is neoplasm.