TLR9 and neoplasm: It should be noted that the growth inhibition of human DMPM xenografts was observed in mice injected with a murine specific TLR9 agonist, making unlikely that the observed antitumor activity was ascribable to a direct interaction between CpG-ODN1826 and tumor cells, as different CpG-ODN sequences are required for stimulation of mouse and human TLR9-positive cells.