A third group of cancers had significantly lower CREB3L1 mRNA expression than the corresponding normal tissues, including: lung squamous cell carcinoma (p = 1.7 × 10−19), clear cell kidney carcinoma (p = 1.2 × 10−10), papillary kidney carcinoma (p = 1.2 × 10−10), bladder urothelial carcinoma (p = 2.8 × 10−6), colon adenocarcinoma (p = 0.00010), pheochromocytoma and paraganglioma (p = 0.0029), rectal adenocarcinoma (p = 0.0057), cutaneous melanoma (p = 0.043) and cervical squamous cell carcinoma (p = 0.046). Here, CREB3L1 is linked to hereditary pheochromocytoma-paraganglioma.