Several tumor tissues had little or no change in CREB3L1 mRNA expression as compared to normal tissue, including esophageal cancer, glioblastoma multiforme, head and neck squamous cell carcinoma, lung adenocarcinoma, sarcoma, papillary thyroid carcinoma, thymoma and uterine corpus endometrial carcinoma. Here, CREB3L1 is linked to esophageal cancer.