The analysis of CREB3L1 DNA methylation in breast tumors in the TCGA database, also with suggested CpG sites 238 and 259 (i.e., region number 2), were usually more methylated in tumors with low CREB3L1 mRNA expression (Additional file 11: Figure S7), but were generally less methylated in breast tumors than in normal breast tissue (Additional file 9: Figure S5a). Here, CREB3L1 is linked to breast neoplasm.