These findings suggest that HER2-specific IR700 fluorescence persists through specific membrane binding with trastuzumab, whereas IR700 fluorescence from nonspecific tumor vessel volume and/or blood pools is distributed similar to in normal tissues (Fig. 3a, b); based on these findings, we irradiated NIR light for IR700-localizing tumors on Day 1 after Tra-IR700 injection. This evidence concerns the gene ERBB2 and neoplasm.