COMT and Behcet disease: The other inconsistent results for genes associated with dopamine were for COMT with studies reporting hypomethylation of membrane-bound (MB-) COMT in SZ and BD [52], hypomethylation of COMT (isoform not specified) in SZ (but not BD) [51], hypermethylation of soluble (S-) COMT in SZ [34], differential methylation of COMT domain containing 1 (COMTD1) promoter in SZ [37] and a lack of differential methylation of S-COMT promoter in SZ [36].