Using a well-characterised variant at the LPA locus, the authors of a large MR study reported strong associations of T2DM risk with Lp(a) concentrations, however no evidence of a causal link (OR 1.03; 95 % CI 0.96 to 1.10; p = 0.41; 10,088 cases, 68,346 controls) [42]. This evidence concerns the gene LPA and type 2 diabetes mellitus.