We next studied the time course of the expression of ADAMTS proteoglycanases (ADAMTS-1, −4, −5, −9) in the lumbar spinal cord of SOD1G93A and age-matched WT mice by RT-PCR at key time points of ALS progression (eg. presymptomatic (PS), symptomatic (SS) and end (ES) stages). This evidence concerns the gene ADAMTS1 and amyotrophic lateral sclerosis.