MMP3 and amyotrophic lateral sclerosis: While deregulated expression of ADAMTS proteoglycanases has been previously reported during acute CNS injuries, such as stroke [7–9] and spinal cord injury [5, 6, 10], the expression and function of ADAMTS proteoglycanases have not been studied in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).