Among the neurotrophic factors modulated by ADAMTS-4, NGF is of particular interest as it exerts dual roles on neuronal survival/cell death depending on whether it activates the tyrosine kinase receptor TrkA or the tumor necrosis factor receptor p75NTR [42], two receptors induced after injury and in ALS [43, 44]. This evidence concerns the gene NGFR and amyotrophic lateral sclerosis.