These H/K‐ATPase:IL‐1β transgenic mice spontaneously develop inflammation, atrophy, metaplasia, and gastric adenocarcinomas in 30% of mice by 18 months of age.119 When infected with H. felis, tumor development in these mice is accelerated and occurs within 1 year of age, thereby confirming a link between elevated IL‐1β and an increased risk for inflammation‐associated GC.119. Here, IL1B is linked to gastric adenocarcinoma.