KRAS and neoplasm: The small GTP‐binding protein K‐Ras belongs to the superfamily of RAS‐like GTPases and regulates cell‐cycle progression, apoptosis, and senescence and activates somatic mutations in K‐RAS lock the protein in a GTP‐bound, permanently active form.142 While less prevalent than other mutations, activating mutations in K‐RAS have also been observed in GC, and these have been shown to promote proliferation and tumor cell invasiveness.142