Of note, pharmacological inhibition of FASN by cerulenin induces death of human breast cancer cells (ZR-75-1, SKBR3, MCF-7 cells) [36], delays progression in xenograft model of ovarian cancer [37], suppresses DNA replication, and induces apoptosis in HCT116 colon carcinoma cell lines, HL60 promyelocytic leukemia cells and MCF-7 breast cancer cell line [38]. The gene discussed is FASN; the disease is leukemia.